Current Research

Structures

Structures determined by the Hinck laboratory, or in a few cases by others in collaboration with members of the Hinck laboratory, are listed below along with their corresponding PDB code and primary citation.

Sample images are provided in the image gallery (note, if you click on the thumbnails, this will display a larger image and provide additional information).  

Structures are arranged in descending order (with respect to the date that they were deposited in the PDB).

 

  1. miniTGF-β2-7M:TβRII complex,  PDB 5TX4,  Kim, et al., J. Biol. Chem., 292, 7173-7188 (2017) [PDF].
  2. miniTGF-β2-7M,  PDB 5TX6Kim, et al., J. Biol. Chem., 292, 7173-7188 (2017) [PDF].
  3. miniTGF-β2,  PDB 5TX2Kim, et al., J. Biol. Chem., 292, 7173-7188 (2017) [PDF].
  4. Activin-Like Receptor 1 (Alk1) Extracellular Domain, PDB 2LCR, Mahlawat, et al., Biochemistry, 51, 6328-6341 (2012) [PDF].
  5. Activin-Like Receptor 5 (Alk5), also known as the TGF-β type I receptor (TβRI), extracellular domain, PDB 2L5S, Zúñiga, et al., J. Mol. Biol., 412,601-618 (2011). [PDF]
  6. TGF-β1:TβRII:TβRI Complex, PDB 3KFD, Radaev, et al., J. Biol. Chem., 285, 14806-14 (2010). [PDF].
  7. Signal Recognition Particle 54 kDa Protein M-domain (SRP54M), PDB 2JQE, Ilangovan, et al.,  J. Biomol. NMR, 41, 241-248 (2008). [PDF].
  8. TGF-β3:TβRII:TβRI Complex, PDB 2PJY, Groppe, et al., Mol. Cell, 29, 157-68 (2008). [PDF].
  9. Dynein Light Chain 7 (DLC7), PDB 1Z09, Ilangovan, et al., J. Mol. Biol., 352, 338-354 (2005)[PDF].
  10. TGF-β Type II Receptor Extracellular Domain (TβRII), PDB 1PLO, Deep, et al., Biochemistry, 42, 10126-10139 (2003). [PDF]
  11. TGF-β3:TβRII Complex, PDB 1KTZ, Hart, et al., Nat. Struct. Biol., 9, 203-208 (2002). [PDF]
  12. Signal Recognition Particle 19 kDa Protein (SRP19), PDB 1KVV and 1KVN, Pakhomova, et al., J. Mol. Biol., 317, 145-158 (2002). [PDF].
  13. RNA-bound form of Ribosomal Protein L11 C-terminal Domain (L11-C76), PDB 1FOY and 2FOW, Hinck, et al., J. Mol. Biol., 274, 101-113 (1997). [PDF].
  14. HIV Protease Complex with the Inhibitor DMP323, PDB 1BVG and 1BVE, Yamazaki, et al., Prot. Sci., 5, 495-506 (1996). [PDF].
  15. TGF-β1, PDB 1KLA, 1KLC, and 1KLD, Hinck, et al., Biochemistry,  35, 8517-8534 (1996). [PDF].